Why identical mutations cause different types of cancer: Cancer development is influenced by tissue type

Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in precursor cells of the pancreas or the bile duct leads to fundamental different outcomes. This is caused by tissue-specific genetic interactions.

Image: Magdalena Jooss / TUM

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