Exploring the pathogenic roles of enhanced c-Rel function in cancer

Dr. rer. nat. Vanesa Fernández-Sáiz

Technical University of Munich
School of Medicine
Department of Hematology and Oncology(link is external)

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Prof. Dr. rer. nat. Marc Schmidt-Supprian

Technical University of Munich
School of Medicine
Institute of Experimental Hematology(link is external)
TranslaTUM(link is external)

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Project Summary


The transcription factor c-Rel, central to innate and adaptive immune responses, is directly implicated in oncogenesis. However, the mechanisms by which c-Rel alterations drive human hematopoietic and solid cancers remain unresolved. To address this issue, we established mice that allow for cell type-specific enhanced c-Rel expression and visualization. We will employ these and complementary loss of function models as well as advanced proteomic approaches to define tumor cell-intrinsic roles of c-Rel signaling in lymphoma and colorectal cancer, as well as mechanisms and consequences of c-Rel activity within the tumor immune environment.