Mechanisms of immune evasion caused by aberrant innate nucleic acid receptor signaling in tumor cells and their tumor microenvironment


Project Summary

Type I interferons (IFN-I) induced by innate immune signaling pathways in immune and tumor cells are emerging as intriguing determinants of both anti-melanoma responses as well as immune escape and resistance mechanisms. In this proposal, we aim to understand the distinct contribution of IFN-I inducing nucleic acid receptor pathways in tumor and host cells during development and immunosurveillance of melanoma as well as to identify the mechanisms that drive disease resistance.