Tumor-intrinsic vs. microenvironment dependent roles of IL-1 secretion and signaling in melanoma
Prof. Dr. med. Veit Hornung
Gene Center and Department of Biochemistry(link is external)
IL-1α and IL-1β are cytokines with pleiotropic activities that have been associated with inflammation, tissue repair and the regulation of adaptive immune responses. IL-1 secretion in the context for chronic inflammation has also been linked to the development and progression of cancer, most prominently malignant melanoma. In this project, we will dissect the role of IL-1 activation and secretion for melanoma dedifferentiation and progression both within the microenvironment, as well as within the tumor itself. We expect that these studies will allow us to dissect the pleiotropic role of IL-1 signaling in cancer, using melanoma as a model system.
Veit Hornung has received an Advanced Grant from the European Research Council for the study of pivotal components of the innate immune system.
Image: Jan Greune / LMU
de Oliveira Mann, C. C. and Hornung, V. (2021). Eur J Immunol 51, 1897-1910.
Bauernfried, S., Scherr, M. J., Pichlmair, A., Duderstadt, K. E., Hornung, V. (2021). Science 371.
Linder, A., Bauernfried, S., Cheng, Y., Albanese, M., Jung, C., Keppler, O. T., Hornung, V. (2020). EMBO J, e105071.
Paludan, S.R., Reinert, L.S., Hornung, V. (2019). Nat Rev Immunol 19, 141-153.