Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis

Coleman, O.I., Lobner, E.M., Bierwirth, S., Sorbie, A., Waldschmitt, N., Rath, E., Berger, E., Lagkouvardos, I., Clavel, T., McCoy, K.D., Weber, A., Heikenwalder, M., Janssen, K.P., Haller, D. (2018). Gastroenterology 155, 1539-1552 e1512.

DOI: 10.1053/j.gastro.2018.07.028(link is external)


Background & Aims
Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. We studied whether ATF6 contributes to the development of colorectal cancer (CRC) using tissue from patients and transgenic mice.