Mechanisms of inflammatory Card9 signaling in intestinal carcinogenesis

  

Project Summary


High-grade inflammation in chronic inflammatory bowel disease (IBD) and smoldering tumor-elicited inflammation are key drivers of colorectal cancer, but the mechanisms that link inflammatory signaling to intestinal carcinogenesis are insufficiently understood. Since polymorphisms in Card9 are associated with human IBD, we have studied the function of Card9 in colitis-associated cancer (CAC). Deficiency for Card9 amongst others results in impaired tumor development and defective tumor cell-intrinsic STAT3 activation. Here, we want to define the mechanism of Card9 signaling during CAC and investigate the functions and consequences of these pathways for tumor-elicited inflammation in oncogene-driven colon cancer.

A research team led by LMU biologist Barbara Schraml has shown that a specific subtype of immune cells protects the kidney from damage by toxins.

Image: Barbara Schraml, Stephan Rambichler / LMU

A research team at the Technical University of Munich (TUM) has now found a possible cause for these self-destructive immune system attacks: a hyperactive RANK protein on the surface of B cells.

Image: Andreas Heddergott / TUM

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A study by LMU researchers shows that putatively immature dendritic cells found in young children are able to induce robust immune responses. The results could lead to improved vaccination protocols.

Image: Barbara Schraml, Stephan Rambichler / LMU

The professor of clinical chemistry is honored for his outstanding scientific work in the field of immunology, as announced by the German Research Foundation (DFG)

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The European Research Council (ERC) is funding a project by Prof. Dr. Jürgen Ruland with a renowned Advanced Grant.

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