Inflammatory pathways in subtypes of intestinal cancer


Project Summary

Inflammatory signals induced by tumor cells or the host environment are closely linked to cancer progression and treatment resistance. Our preliminary data suggest that the mutational make-up of the primary tumor dictates the pro- and anti-tumorigenic immune response, which in turn determines tumor progression and survival. We aim to systematically decipher inflammatory pathways in subtypes of intestinal cancer and to evaluate the contribution of different immune cell subsets and inflammatory signals to cancer initiation and progression.