Dear Colleagues,

The field of immuno-oncology has introduced novel concepts for the treatment of cancer, that harness the power of the immune system to detect and destroy malignant cells. However, dysfunctional signals in the immune system can suppress antitumor immune responses and drive the development of cancer by creating tumor-promoting inflammatory environments. Moreover, oncogenic mutations within immune cells that deregulate immune receptor signaling pathways are frequent causes of leukemias and lymphomas.

To address key questions and current concepts on tumor-immune-cell interactions, mechanisms of malignant lymphocyte transformation and ongoing efforts that exploit immune signals for cancer therapies, we will bring together world-leading immunologists and cancer researchers. Furthermore, the event will cover state-of-the-art technologies that explore immune function and metabolism in cancer at the organism, tissue, and cellular level.

We are very much looking forward to welcoming you at our symposium.
With best wishes,

Jürgen Ruland
Spokesperson of the CRC 1335

On behalf of the organizing Committee:
Florian Bassermann, Maike Buchner, Mathias Heikenwälder, Veit Hornung, Hendrik Poeck, Jürgen Ruland, Marc Schmidt-Supprian




Thursday, 2nd December 2021
1:00 pm - 6:30 pm
 



1:00 pm

Welcome

Jürgen Ruland

Immune Metabolism in Cancer 

Chairs: Mathias Heikenwälder, Julia Jellusova


1:10 pm
Ping-Chih Ho
Friend or foe: lipid metabolism in tumor-associated macrophages
1:40 pm
Theodore Alexandrov
Spatial single-cell metabolomics reveals metabolic cell states
2:10 pm
Russel Jones
Environmental impact on T cell metabolism

2:40 pm

Break

Immune Signals and Targets in Lymphoma

Chairs: Maike Buchner, Julia Hauer


3:00 pm
Teresa Palomero
Mechanisms of Transformation in Peripheral T-cell Lymphomas
3:30 pm
Salvia Jain
Biomarkers of response and resistance to CD47-SIRPa immunotherapy in T-cell lymphomas
4:00 pm
Ari M. Melnick
Epigenetic mechanisms driving transformation of the immune system

4:30 pm

Break

Immune Recognition of Cancer Cells

Chairs: Barbara Schraml, Simon Heidegger


4:50 pm
Timothy Chan
How Immune Cells Recognize and Target Tumor Cells
5:20 pm
Michael Hölzel
Exploring Principles of T-cell Therapy in Melanoma
5:50 pm
Caetano Reis e Sousa
Keynote Lecture
Necrophagia, DaNGeRous Indigestion and Immunity to Cancer



Friday, 3rd December 2021
1:00 pm - 5:30 pm
 

Innate Immunity and Inflammation in Cancer

Chairs: Dieter Saur, Marc Schmidt-Supprian


1:00 pm
Triantafyllos Chavakis
Trained Granulopoiesis in Cancer
1:30 pmFlorian Greten
Cell Plasticity in Colorectal Carcinogenesis
2:00 pm
Andrea Ablasser
Sensing DNA as a Danger Signal Through the cGAS-STING Pathway

2:30 pm

Break

Immune Recognition of Cancer Cells

Chair: Oliver Weigert, Hendrik Poeck


2:50 pm
Andy J. Minn
Decoding and Recoding the Opposing Roles of Interferon and Pattern Recognition Receptor Signaling in Cancer Immunotherapy
3:20 pm
Nir Hacohen
Keynote Lecture

Cell types, States and Programs Unnderlying Human Immune Response

4:15 pm

Closing Remarks

Florian Bassermann