Comparative animal pathology core and tissue cohort outreach

Prof. Dr. med. Wilko Weichert

Technical University of Munich
Institute of Pathology(link is external)

E-Mail(link sends e-mail)

  

Project Summary


Z01 provides an already established and fully equipped morphomolecular comparative experimental pathology platform aiming at cutting-edge animal phenotyping supplemented by a comparative human tissue cohort outreach for the assessment of the complex roles of aberrant intrinsic and extrinsic immune cell signaling in cancer. Thus, this central project will support all subprojects in the implementation of translational tissue-based morphomolecular analyses of (pre-)neoplastic cells and immune cells into their research programs, which will greatly facilitate the valid interpretation of genotype-phenotype correlations.

Schmitt, M., Silva, M., Konukiewitz, B., Lang, C., Steiger, K., Halfter, K., Engel, J., Jank, P., Pfarr, N., Wilhelm, D., Foersch, S., Denkert, C., Tschurtschenthaler, M., Weichert, W., Jesinghaus, M. (2021). Cancers 13.

DOI:10.3390/cancers13246177


Wahida, A., Muller, M., Hiergeist, A., Popper, B., Steiger, K., Branca, C., Tschurtschenthaler, M., Engleitner, T., Donakonda, S., De Coninck, J., Ollinger, R., Pfautsch, M.K., Muller, N., Silva, M., Usluer, S., Thiele Orberg, E., Bottcher, J.P., Pfarr, N., Anton, M., Slotta-Huspenina, J.B., Nerlich, A.G., Madl, T., Basic, M., Bleich, A., Berx, G., Ruland, J., Knolle, P.A., Rad, R., Adolph, T.E., Vandenabeele, P., Kanegane, H., Gessner, A., Jost, P.J., Yabal, M. (2021). Sci Immunol 6, eabf7235.

DOI:10.1126/sciimmunol.abf7235


Konukiewitz, B., Schmitt, M., Silva, M., Pohl, J., Lang, C., Steiger, K., Halfter, K., Engel, J., Schlitter, A.M., Boxberg, M., Pfarr, N., Wilhelm, D., Foersch, S., Tschurtschenthaler, M., Weichert, W., Jesinghaus, M. (2021). Br J Cancer.

DOI:10.1038/s41416-021-01553-0


Salei, N., Ji, X., Pakalniskyte, D., Kuentzel, V., Rambichler, S., Li, N., Moser, M., Steiger, K., Buch, T., Anders, H.J., Schraml, B.U. (2021). Proc Natl Acad Sci U S A 118.

DOI:10.1073/pnas.2022311118


Lewis, R., Maurer, H. C., Singh, N., Gonzalez-Menendez, I., Wirth, M., Schick, M., Zhang, L., Isaakidis, K., Scherger, A. K., Schulze, V., Lu, J., Zenz, T., Steiger, K., Rad, R., Quintanilla-Martinez, L., Espeli, M., Balabanian, K., Keller, U., Habringer, S. (2021). Leukemia.

DOI:10.1038/s41375-021-01376-1(link is external)


Jesinghaus, M., Schmitt, M., Lang, C., Reiser, M., Scheiter, A., Konukiewitz, B., Steiger, K., Silva, M., Tschurtschenthaler, M., Lange, S., Foersch, S., Becker, K. F., Saur, D., Friess, H., Halfter, K., Engel, J., Boxberg, M., Pfarr, N., Wilhelm, D., Weichert, W. (2021). Am J Surg Pathol 45, 969-978.

DOI:10.1097/PAS.0000000000001692(link is external)


Dreyer, T. F., Kuhn, S., Stange, C., Heithorst, N., Schilling, D., Jelsma, J., Sievert, W., Seitz, S., Stangl, S., Hapfelmeier, A., Noske, A., Wege, A. K., Weichert, W., Ruland, J., Schmitt, M., Dorn, J., Kiechle, M., Reuning, U., Magdolen, V., Multhoff, G., Bronger, H. (2021). Cancer Immunol Res 9, 779-789.

DOI:10.1158/2326-6066.CIR-20-0327(link is external)


Ecker, V., Stumpf, M., Brandmeier, L., Neumayer, T., Pfeuffer, L., Engleitner, T., Ringshausen, I., Nelson, N., Jucker, M., Wanninger, S., Zenz, T., Wendtner, C., Manske, K., Steiger, K., Rad, R., Muschen, M., Ruland, J., Buchner, M. (2021). Nat Commun 12, 3526.

DOI:10.1038/s41467-021-23752-2(link is external)


Alankus, B., Ecker, V., Vahl, N., Braun, M., Weichert, W., Macher-Goppinger, S., Gehring, T., Neumayer, T., Zenz, T., Buchner, M., Ruland, J. (2021). J Exp Med 218.

DOI:10.1084/jem.20200517(link is external)


Munkhbaatar, E., Dietzen, M., Agrawal, D., Anton, M., Jesinghaus, M., Boxberg, M., Pfarr, N., Bidola, P., Uhrig, S., Hockendorf, U., Meinhardt, A. L., Wahida, A., Heid, I., Braren, R., Mishra, R., Warth, A., Muley, T., Poh, P. S. P., Wang, X., Frohling, S., Steiger, K., Slotta-Huspenina, J., van Griensven, M., Pfeiffer, F., Lange, S., Rad, R., Spella, M., Stathopoulos, G. T., Ruland, J., Bassermann, F., Weichert, W., Strasser, A., Branca, C., Heikenwalder, M., Swanton, C., McGranahan, N., Jost, P. J. (2020). Nat Commun 11, 4527.

DOI:10.1038/s41467-020-18372-1


Biederstadt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H. P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Muller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. (2020). Gut 69, 1472-1482.

DOI:10.1136/gutjnl-2018-317856


Heidegger, S., Wintges, A., Stritzke, F., Bek, S., Steiger, K., Koenig, P. A., Gottert, S., Engleitner, T., Ollinger, R., Nedelko, T., Fischer, J. C., Makarov, V., Winter, C., Rad, R., van den Brink, M. R. M., Ruland, J., Bassermann, F., Chan, T. A., Haas, T., Poeck, H. (2019). Sci Immunol 4.

DOI:10.1126/sciimmunol.aau8943(link is external)


Schug, C., Kitzberger, C., Sievert, W., Spellerberg, R., Tutter, M., Schmohl, K. A., Eberlein, B., Biedermann, T., Steiger, K., Zach, C., Schwaiger, M., Multhoff, G., Wagner, E., Nelson, P. J., Spitzweg, C. (2019). Clin Cancer Res 25, 5997-6008.

DOI:10.1158/1078-0432.Ccr-18-4092(link is external)


Scherger, A.K., Al-Maarri, M., Maurer, H.C., Schick, M., Maurer, S., Ollinger, R., Gonzalez-Menendez, I., Martella, M., Thaler, M., Pechloff, K., Steiger, K., Sander, S., Ruland, J., Rad, R., Quintanilla-Martinez, L., Wunderlich, F.T., Rose-John, S., Keller, U. (2019). JCI Insight 4.

DOI: 10.1172/jci.insight.128435(link is external)


Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H.E., Roelli, P., Utzschneider, D.T., von Hoesslin, M., Cullen, J.G., Fan, Y., Eisenberg, V., Wohlleber, D., Steiger, K., Merkler, D., Delorenzi, M., Knolle, P.A., Cohen, C.J., Thimme, R., Youngblood, B., Zehn, D. (2019). Nature 571, 265-269.

DOI: 10.1038/s41586-019-1326-9(link is external)


Rosenbaum, M., Gewies, A., Pechloff, K., Heuser, C., Engleitner, T., Gehring, T., Hartjes, L., Krebs, S., Krappmann, D., Kriegsmann, M., Weichert, W., Rad, R., Kurts, C., Ruland, J. (2019). Nat Commun 10, 2352.

DOI: 10.1038/s41467-019-10203-2(link is external)


Albers, J.J., Ammon, T., Gosmann, D., Audehm, S., Thoene, S., Winter, C., Secci, R., Wolf, A., Stelzl, A., Steiger, K., Ruland, J., Bassermann, F., Kupatt, C., Anton, M., Krackhardt, A.M. (2019). Life Sci Alliance 2.

DOI: 10.26508/lsa.201900367(link is external)


Weber, J., de la Rosa, J., Grove, C.S., Schick, M., Rad, L., Baranov, O., Strong, A., Pfaus, A., Friedrich, M.J., Engleitner, T., Lersch, R., Ollinger, R., Grau, M., Menendez, I.G., Martella, M., Kohlhofer, U., Banerjee, R., Turchaninova, M.A., Scherger, A., Hoffman, G.J., Hess, J., Kuhn, L.B., Ammon, T., Kim, J., Schneider, G., Unger, K., Zimber-Strobl, U., Heikenwalder, M., Schmidt-Supprian, M., Yang, F., Saur, D., Liu, P., Steiger, K., Chudakov, D.M., Lenz, G., Quintanilla-Martinez, L., Keller, U., Vassiliou, G.S., Cadinanos, J., Bradley, A., Rad, R. (2019). Nat Commun 10, 1415.

DOI: 10.1038/s41467-019-09180-3(link is external)