Publications



SUMO pathway inhibition targets an aggressive pancreatic cancer subtype


Biederstadt, A., Hassan, Z., Schneeweis, C., Schick, M., Schneider, L., Muckenhuber, A., Hong, Y., Siegers, G., Nilsson, L., Wirth, M., Dantes, Z., Steiger, K., Schunck, K., Langston, S., Lenhof, H. P., Coluccio, A., Orben, F., Slawska, J., Scherger, A., Saur, D., Muller, S., Rad, R., Weichert, W., Nilsson, J., Reichert, M., Schneider, G., Keller, U. (2020). Gut 69, 1472-1482.

DOI:10.1136/gutjnl-2018-317856

Analysis pipelines for cancer genome sequencing in mice


Lange, S., Engleitner, T., Mueller, S., Maresch, R., Zwiebel, M., Gonzalez-Silva, L., Schneider, G., Banerjee, R., Yang, F. T., Vassiliou, G. S., Friedrich, M. J., Saur, D., Varela, I., Rad, R. (2020). Nat Protoc 15, 266-315.

DOI:10.1038/s41596-019-0234-7(link is external)

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice


Healy, M. E., Boege, Y., Hodder, M. C., Bohm, F., Malehmir, M., Scherr, A. L., Jetzer, J., Chan, L. K., Parrotta, R., Jacobs, K., Clerbaux, L. A., Kreutzer, S., Campbell, A., Gilchrist, E., Gilroy, K., Rodewald, A. K., Honcharova-Biletska, H., Schimmer, R., Velez, K., Bueler, S., Cammareri, P., Kalna, G., Wenning, A. S., McCoy, K. D., Gomez de Aguero, M., Schulze-Bergkamen, H., Klose, C. S. N., Unger, K., Macpherson, A. J., Moor, A. E., Kohler, B., Sansom, O. J., Heikenwalder, M., Weber, A. (2020). Gastroenterology 159, 183-199.

DOI:10.1053/j.gastro.2020.03.017(link is external)

Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses


Mueller, S., Lange, S., Collins, K. A. N., Krebs, S., Blum, H., Schneider, G., Rad, L., Saur, D., Rad, R. (2020). Nat Commun 11, 4474.

DOI:10.1038/s41467-020-18095-3(link is external)

Ubiquitination and Ubiquitin-Like Modifications in Multiple Myeloma: Biology and Therapy


Wirth, M., Schick, M., Keller, U., Kronke, J. (2020). Cancers (Basel) 12, 3764.

DOI:10.3390/cancers12123764

CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma


Herhaus, P., Lipkova, J., Lammer, F., Yakushev, I., Vag, T., Slotta-Huspenina, J., Habringer, S., Lapa, C., Pukrop, T., Hellwig, D., Wiestler, B., Buck, A. K., Deckert, M., Wester, H. J., Bassermann, F., Schwaiger, M., Weber, W., Menze, B., Keller, U. (2020). Journal of Nuclear Medicine 61, 1765-1771.

DOI:10.2967/jnumed.120.241703(link is external)

Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System


Vornholz, L. and Ruland, J. (2020). Curr Top Microbiol Immunol 429, 177-203.

DOI:10.1007/82_2020_211(link is external)

Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System


Hong, Y., Singh, N., Bamopoulos, S., Gjerga, E., Schmalbrock, L. K., Balabanian, K., Schick, M., Keller, U., Wirth, M. (2020). Biomedicines 8, 590.

DOI:10.3390/biomedicines8120590(link is external

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms


Jayavelu, A. K., Schnoder, T. M., Perner, F., Herzog, C., Meiler, A., Krishnamoorthy, G., Huber, N., Mohr, J., Edelmann-Stephan, B., Austin, R., Brandt, S., Palandri, F., Schroder, N., Isermann, B., Edlich, F., Sinha, A. U., Ungelenk, M., Hubner, C. A., Zeiser, R., Rahmig, S., Waskow, C., Coldham, I., Ernst, T., Hochhaus, A., Jilg, S., Jost, P. J., Mullally, A., Bullinger, L., Mertens, P. R., Lane, S. W., Mann, M., Heidel, F. H. (2020). Nature 588, 157-163.

DOI:10.1038/s41586-020-2968-3(link is external)

Inhibition of LTbetaR signalling activates WNT-induced regeneration in lung


Conlon, T. M., John-Schuster, G., Heide, D., Pfister, D., Lehmann, M., Hu, Y., Ertuz, Z., Lopez, M. A., Ansari, M., Strunz, M., Mayr, C., Ciminieri, C., Costa, R., Kohlhepp, M. S., Guillot, A., Gunes, G., Jeridi, A., Funk, M. C., Beroshvili, G., Prokosch, S., Hetzer, J., Verleden, S. E., Alsafadi, H., Lindner, M., Burgstaller, G., Becker, L., Irmler, M., Dudek, M., Janzen, J., Goffin, E., Gosens, R., Knolle, P., Pirotte, B., Stoeger, T., Beckers, J., Wagner, D., Singh, I., Theis, F. J., de Angelis, M. H., O'Connor, T., Tacke, F., Boutros, M., Dejardin, E., Eickelberg, O., Schiller, H. B., Konigshoff, M., Heikenwalder, M., Yildirim, A. O. (2020). Nature 588, 151-156.